Structural MRI markers of brain aging early after ischemic stroke

E Werden; T Cumming; Q Li; L Bird; M Veldsman; HR Pardoe; G Jackson; GA Donnan; A Brodtmann

Journal article

Structural MRI markers of brain aging early after ischemic stroke

E Werden, T Cumming, Q Li, L Bird, M Veldsman, HR Pardoe, G Jackson, GA Donnan, A Brodtmann

Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017

DOI: 10.1212/WNL.0000000000004086

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Abstract

Objective: To examine associations between ischemic stroke, vascular risk factors, and MRI markers of brain aging. Methods: Eighty-one patients (mean age 67.5 ± 13.1 years, 31 left-sided, 61 men) with confirmed first-ever (n = 66) or recurrent (n = 15) ischemic stroke underwent 3T MRI scanning within 6 weeks of symptom onset (mean 26 ± 9 days). Age-matched controls (n = 40) completed identical testing. Multivariate regression analyses examined associations between group membership and MRI markers of brain aging (cortical thickness, total brain volume, white matter hyperintensity [WMH] volume, hippocampal volume), normalized against intracranial volume, and the effects of vascular risk factor..

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University of Melbourne Researchers

Emilio Werden Author

Heath Pardoe Author

Graeme Jackson Author

Geoffrey Donnan Author

Related Projects (1)

EPILEPSY: A 'PATIENT TO BENCH AND BACK TO PATIENT' PROGRAM ABOUT UNDERSTANDING THE CAUSES OF SEIZURE DISORDERS.

The team is comprised of neurologists, molecular geneticists, physiologists and brain imaging specialists and leads the world in the discove..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council project grant (APP1020526), Brain Foundation, Wicking Trust, Collie Trust, and Sidney and Fiona Myer Family Foundation. The Florey Institute of Neuroscience and Mental Health acknowledges the support received from the Victorian Government via the Operational Infrastructure Support Scheme.